Military dual use, export control and ozone depleting chemicals

Chemical companies and suppliers must ensure that they comply with national and international regulations relating to the supply of chemicals. Many of these cover common chemicals that can also be used illicit or military purposes, and for which supply or export is restricted and monitored or reportable.

Legislation in this area includes drug precursors, military dual use, human rights lists, ozone depleting chemicals and chemical weapons and their precursors. Within the USA many of these are enacted within Commerce Control Lists (CCL) and ITAR (International Traffic in Arms Regulations)

The challenge with these regulations is that they do not just control single substances, but also defined chemically similar substances – for example, the following relates to chemicals that can be used as precursors for chemical weapons.

O-Alkyl (H equal to or less than C10, including cycloalkyl) O-2-dialkyl (Methyl, Ethyl, n-Propyl or Isopropyl)-aminoethyl alkyl (Methyl, Ethyl, n-Propyl or Isopropyl) phosphonites and corresponding alkylated and protonated salts

Even when a single substance is specifically named or identified by a CAS number or similar, this is usually given as only guidance – an example a single salt form amongst many.

Therefore, relying on the traditional approach of lists of CAS numbers or chemical names does not provide for robust or adequate control.

To address these challenges and improve compliance Scitegrity encode all the above legislation and more in Controlled Substances Squared to allow it to be searched via chemical structure.

Simply search for a chemical by name, draw it in, paste in a smiles, inchi or upload a file of structures to check. Controlled Substances Squared will then tell you if, how, why and where its regulated with links through to regulators for licensing and reporting information. This is done by comparing the chemical structure to the rules and structures within the legislation - not by name matching, thus allowing even novel and proprietary chemicals to be checked.

Below is a short 3 minute video giving an overview of Controlled Substances Squared.


Features include


>  Choose from our Enterprise or Hosted Plans. Enterprise sits behind your firewall for complete security, while our hosted version offers per user instant access with no software to install. You can also choose to access Hosted via Webservices to automate your checks. Or if you prefer you can send us your structures under NDA and we'll check them for you and report back controlled substances.

>  Searches are based on structure rather than words / CAS number etc - upload or draw your compounds structure to check.

>  Fast - scan collections of millions of compounds quickly to identify controlled substances. Automatic overnight scans check newly made substances and legislation amendments.

>  Flexible - search by structure, names and synonyms giving in legislation and more. Setup ‘favourites’ to speed searches. Schedule automatic overnight checks of your chemical collection(s) which allow people to search on and use your own internal chemical IDs.

>  Comprehensive - select the countries the compounds will be stored in or shipped to.  26+ core countries covered with more that can be added rapidly, click here of a full list.

>  Robust searches extend to markushes, isomers, salts, esters, ethers, analogues etc. (where applicable) to ensure total compliance.

>  Up-to date - legislation changes are automatically picked up by the system, with optional alerts for user of changes. Copies of the legislation along with additional guidance can be accessed with a single click.

>  Customisable – add your own additional substances, restrictions, guidance, documents and chemical rules. Generate summary pdf reports from searches.

>  Easy integration with internal systems - REST webservices, Pipeline Pilot components and Oracle views. Scan compounds before you even make them or automatically scan every compound shipped or purchased.

>  CisPro plugin allows for easy out of the box integration. CS2 has also been integrated with many other LIMs, ELNs, Sample Management systems


Originally developed in conjunction with several major Pharmaceutical R&D companies, Controlled Substances Squared also covers controlled drug legislation from around the world.

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Keywords:- Controlled Substance Compliance Software, Controlled Drug Compliance Software, DEA compliance, Controlled chemicals, Controlled compounds, Drug Precursor identification, Drug Precursor compliance

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